Monitor the patient’s clinical state and serum lithium concentrations regularly. Tablets: 300 mg to 600 mg, two to three times daily.Titrate to serum lithium concentrations between 0.8 and 1 mEq/L, which may be achieved in adults with: Dosage for Maintenance Treatment of Bipolar I Disorder Adjust daily dosage based on serum lithium concentration and clinical response. Obtain serum lithium concentrations regularly until the serum concentration and clinical condition of the patient has stabilized. Tablets: 600 mg, two to three times daily.Titrate to serum lithium concentrations between 0.8 and 1.2 mEq/L, which may be achieved in adults with: Dosage for Acute Treatment of Manic Episodes in Bipolar I Disorder These adverse reactions may subside with continued treatment, concomitant administration with food, temporary reduction or cessation of dosage. Transient and mild nausea and general discomfort may also appear during the first few days of lithium administration. Fine hand tremor, polyuria and mild thirst may occur during initial therapy for the acute manic phase, and may persist throughout treatment.
Obtain serum lithium concentration assay after 4 days, drawn 12 hours after the last oral dose. Lithium Carbonate and Lithium Oral Solution Dose Conversion
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